Goldbergs with all repeats and slowish tempi leading to 80 min. or more duration can stretch one's patience, so I think it can be advisable to skip repeats. I usually have no problems with (almost) repeat free Goldbergs of ~40-50 min length and neither with the usually 45-50 min (depending on tempo and repeats, I have one by Anda below 40 min and the excentric Ugorski takes 61 and Anderszewski 63 min) duration of the Diabellis. It's not much longer than many symphonies or longish sonatas (like Schubert's last or LvB op.106).
There are several suggestions for "arcs" in the Diabellis, some posted further above in this thread. I think one can also listen to parts instead of the whole but I'd much rather do this with the GBV (like the first half) than with the Diabellis.